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Study of associations of some genotypes with Diabetic Cardiovascular Autonomic Neuropathy in the Kazakh population

Individual registration number АР14871525

Еxecution period – 2022 -2024

Source of funding - Ministry of Science and Higher Education of the Republic of Kazakhstan (contract №176/30-22-24 18 October 2022).

The head of the research group – Nagymtayeva Almagul Amanzholovna

The project aims to determine the predictive value of the structural variability of the genome, represented by polymorphisms with a previously proven relationship/association with DM2, for the development of CAN in the Kazakh population.

Project tasks.

  1. Collection and compilation of genotypic and phenotypic data on 400 study participants.
  2. Formation of a database of phenotypic and genotypic data for each participant of the study and statistical evaluation of phenotype/genotypic associations.
  3. Epidemiological analysis of the prevalence of the cardiovascular form of diabetic neuropathy (hereinafter - CDN) among 20,000 individuals of the Kazakh population from among the contingent of BMC UDP.
  4. Forming conclusions about the prognostic value of the structural variability of the genome, represented by different genotypes, for the development of CFDN in DM2.

Expected results.

  • Based on new scientific data, a potential molecular target for the prevention of cardiovascular complications of DM2 in the Kazakh population;
  • A presentation at an international conference, at least 2 (two) articles and (or) reviews in peer-reviewed scientific journals indexed in the Science Citation Index Expanded of the Web of Science database and (or) with a CiteScore percentile in the Scopus database less than 35 (thirty five); as well as at least 2 (two) articles or reviews in a peer-reviewed foreign or domestic publication recommended by Committee for Quality Assurance in the Sphere of Education and Science of the Ministry of Education and Science of the Republic of Kazakhstan, methodological recommendations.

Contact details: Nagymtayeva Almagul Amanzholovna
+ 7 (7172) 70-80-90, ext. nom. 8102

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