Department for Science and Gerontology

The Department for Science and Gerontology was set to work within the Hospital in August 2015.

Department Mission

Conducting scientific research in the field of gerontology and anti-aging medicine to promote healthy aging.

Department Vision

Department for Science and Gerontology, carrying out project, methodological and consultation activities in the field of scientific research (aging biology and age-associated diseases), including clinical drugs and technologies testing.

Objectives of the Department

• Methodological support for specialized scientific research;
• Implementation of own scientific projects in the field of gerontology;
• Attraction of funding resources for the implementation of own scientific research;
• Participation in the development of gerontological care at the level of public authority consultation groups;
• Participation in the development of clinical drug testing

Priority areas in scientific and clinical research

• Molecular biology of aging;
• Study of age8-related diseases;
• Study of the impact of social conditions on the aging processes;
• Study of the impact of clinical drug testing

Current scientific research of the Department

Scientific and technical project on the topic: “The development of innovative technologies increasing the diagnosis and treatment efficiency of the cervix background and precancerous diseases associated with the human papillomavirus”

Individual registration number ВR18574160

Execution period: 2023 -2024

Source of funding: Ministry of Science and Higher Education of the Republic of Kazakhstan

The head of the temporary research group: Nasrulla Shanazarov

The project aims. Development of innovative technologies increasing the diagnosis and treatment efficiency of the cervix background and precancerous diseases associated with the human papillomavirus (hereinafter – HPV).

Project tasks.

1. Evaluation of the effectiveness and safety of the applied methods for treatment of the cervix background and precancerous diseases associated with HPV.
2. Development of an improved, effective and safe method for the treatment of the cervix background and precancerous diseases associated with HPV, using laser technologies with photosensitization (hereinafter - PS). 
3. Development of a method for fluorescent diagnostics using PS for cervix background and precancerous diseases associated with HPV.  
4. Development of a method for assessing the “burnout” of PS during local photodynamic therapy (hereinafter - PDT)  
5. Development and implementation of an optimal PDT program for complete eradication of HPV. 

Expected result.

• For the first time, immunological and molecular genetic data will be obtained reflecting the causes of HPV persistence and the duration of its elimination when using complex PDT technology.
• For the first time in the Republic of Kazakhstan, an innovative complex laser technology of light therapy with photosensitization will be developed and used for the treatment of HPV-associated precancerous diseases of the cervix, taking into account the endotype.
• 3 articles will be published in a peer-reviewed scientific publication indexed in the Science Citation Index Expanded of the Web of Science database and (or) having a CiteScore percentile in the Scopus database of at least 50, 3 articles in peer-reviewed foreign or domestic publications recommended by the Committee for Quality Assurance in the Sphere of Education and Science of the Ministry for Education and Science of the Republic of Kazakhstan, abstracts and 2 reports on international scientific and practical conferences, patent of the Kazakhstan Patent Bureau, methodological recommendations, suggestions for periodic clinical protocols, monograph

Contact details: Nasrulla Shanazarov 

+ 7 (7172) 70-80-90, int. number 8081

Research grant project on the topic “Investigation of the types of intestinal microbiota in patients with insulin resistance in the Kazakh population”

Individual registration number АР14871581

Execution period - 2022 -2024

Funding source – Ministry of Science and Higher Education of the Republic of Kazakhstan (contract No. 176/30-22-24 dated October 18, 2022)

The head of the temporary research group – Gulshara Abildinova.

Aim of the project. To determine the predictive value of the species diversity of the intestinal microbiota in case of insulin resistance in the Kazakh population.

Project tasks.

1. Collection and compilation of phenotypic and genotypic data on 200 study participants; 
2. Study of phenotypic associations of study participants using the structure of intestinal microbiota based on sequencing of the 16s ribosomal RNA gene;
3. Formation of conclusions about the possibility of managing insulin resistance in the Kazakh population by modifying the species structure of the intestinal microbiome.

Expected results.

• Based on new scientific data, additional opportunities for the management of insulin resistance in the Kazakh population through the modification of the species structure of the intestinal microbiota in the Kazakh population;
• 2 publications in a peer-reviewed scientific publication indexed in the Science Citation Index Expanded Web of Science database and (or) having a CiteScore percentile in the Scopus database of at least 35, 1 article in a peer-reviewed foreign or domestic publication recommended by CCES, abstracts and 2 reports on international scientific and practical conferences, methodological recommendations.

Contact details: Gulshara Abildinova

+ 7 (7172) 70-80-90, int. number 8134

Research grant project on the topic “Assessment of the prognostic value of structural genome variability for the development of coronary heart disease in type II diabetes mellitus in Kazakhs”

Individual registration number АР14872367

Execution period - 2022 -2024

Funding source – Ministry of Science and Higher Education of the Republic of Kazakhstan (contract No. 176/30-22-24 dated October 18, 2022)

The head of the temporary research group – Raushan Karabayeva

The project aims to determine the predictive value of the structural variability of the genome represented 9 single nucleotide polymorphisms (thereafter – SNPs) rs72652411, rs1011970, rs62560775, rs564398, rs10757278, rs4977574, rs1575972, rs1333051, rs2383208, on chromosome segment 9p21.3, for the development of coronary heart disease (thereafter – CHD) with type 2 diabetes (thereafter – T2D) in persons of the Kazakh population.

Project tasks.

1. Collection and compilation of phenotypic and genotypic data on 600 study participants.
2. Study of phenotype/genotypic associations of study participants with T2D, with CHD, with T2D and CHD, without T2D and CHD.
3. Forming conclusions about the prognostic value of the structural variability of the genome, represented by different genotypes of SNPs in the chromosome segment 9p21.3, for the Kazakh population in comparison with other populations. Evaluation of the possibility to consider the chromosomal segment 9p21.3 as a key molecular mechanism of the pathological interaction of coronary heart disease and T2D. 
4. Development, according to the received scientific data, of recommendations for clinical practice in the Republic of Kazakhstan. 

Expected results.

• Based on new scientific data, a potential molecular target for the prevention, diagnosis and treatment of coronary heart disease and T2D in the Kazakh population. The results of the study, which provide new knowledge about the molecular pathway of CHD and T2D, will expand the understanding of common points in pathogenesis and will have an impact on the directions of future research.
• 3 publications in a peer-reviewed scientific publication indexed in the Science Citation Index Expanded of the Web of Science database and (or) having a CiteScore percentile in the Scopus database of at least 35, 1 article in a peer-reviewed foreign or domestic edition recommended by Committee for Quality Assurance in the Sphere of Education and Science, abstracts and 2 reports at international scientific and practical conferences, a patent for a utility model Kazakhstan Patent Office, methodological recommendations.

Contact details: Raushan Karabayeva

+ 7 (7172) 70-80-90, int. number 8003

Research grant project on the topic “Study of associations of some genotypes with Diabetic Cardiovascular Autonomic Neuropathy in the Kazakh population”

Individual registration number АР14871525

Execution period - 2022 -2024

Funding source – Ministry of Science and Higher Education of the Republic of Kazakhstan (contract No. 176/30-22-24 dated October 18, 2022)

The head of the temporary research group –Valeryi Benberin

Project aims to determine the predictive value of the structural variability of the genome, represented by polymorphisms with a previously proven relationship/association with type 2 diabetes (hereinafter – T2D), for the development of cardiovascular diabetic neuropathy in the Kazakh population.

Project tasks.

1. Collection and compilation of genotypic and phenotypic data on 400 study participants.  
2. Formation of a database of phenotypic and genotypic data for each participant of the study and statistical evaluation of phenotype/genotypic associations. 
3. Epidemiological analysis of the prevalence of the cardiovascular form of diabetic neuropathy (hereinafter - CFDN) among 20,000 individuals of the Kazakh population from among the contingent of MCH PAA.
4. Forming conclusions about the prognostic value of the structural variability of the genome, represented by different genotypes, for the development of CFDN in T2D.

Expected results.

• Based on new scientific data, a potential molecular target for the prevention of cardiovascular complications of T2D in the Kazakh population;
• A presentation at an international conference, at least 2 (two) articles and (or) reviews in peer-reviewed scientific journals indexed in the Science Citation Index Expanded of the Web of Science database and (or) with a CiteScore percentile in the Scopus database less than 35 (thirty five); as well as at least 2 (two) articles or reviews in a peer-reviewed foreign or domestic publication recommended by Committee for Quality Assurance in the Sphere of Education and Science of the Ministry of Education and Science of the Republic of Kazakhstan, methodological recommendations
• 3 publications in a peer-reviewed scientific publication indexed in the Science Citation Index Expanded Web of Science database and (or) having a CiteScore percentile in the Scopus database of at least 35, 2 articles in a peer-reviewed foreign or domestic publication recommended by CCES, abstracts and 2 reports on international scientific and practical conferences, methodological recommendations.

Contact details: Valeryi Benberin

+ 7 (7172) 70-80-90, int. number 8102

Co-execution in the scientific and technical program of the NJSC “Kazakh National Medical University named after S. D. Asfendiyarov”, in the part “The role of genetic factors in the development of arterial hypertension in the Kazakh population”

Individual registration number BR06149195

This project is being carried out by MCH PAA within the framework of the scientific and technical program “National Program for the Introduction of Personalized and Preventive Medicine in the Republic of Kazakhstan”, as a co-executor, the main executor is the Non-Profit Joint Stock Company “Kazakh National Medical University named after S. D. Asfendiyarov”.

Execution period - 2021-2023

Funding source - Ministry of Health of the Republic of Kazakhstan (contract No. 302/08-21 dated August 31, 2021).

The head of the temporary research group – Raushan Karabayeva

Project aims to study the influence of genetic factors in arterial hypertension in the Kazakh population and to develop recommendations for changing clinical practice in Kazakhstan, taking into account the new possibilities of personalized and preventive medicine.

Project tasks.

1. Collection and compilation of phenotypic and genotypic data on 1200 study participants  
2. Study of phenotype-genotype associations in participants with hypertension and response to antihypertensive therapy.
3. Development of recommendations for making changes to the clinical practice of the Republic of Kazakhstan with the aim of using in pharmacotherapy a genetic predisposition to the effectiveness and development of side effects from drug therapy. 

Expected results.

• New scientific data for pharmacotherapy of genetic predisposition to the effectiveness and development of side effects from drug therapy in the Kazakh population;
• 3 publications in a peer-reviewed scientific publication indexed in the Science Citation Index Expanded Web of Science database and (or) having a CiteScore percentile in the Scopus database of at least 35, methodological recommendations, suggestions for periodic clinical protocols of the Republic of Kazakhstan.

Contact details: Raushan Karabayeva

+ 7 (7172) 70-80-90, int. number 8003

Department specialists:

Valeryi Benberin - Chief of the Department, Academician of the National Science Academy of the Republic of Kazakhstan, Professor, Doctor’s degree in Medical sciences;

Tamara Voshchenkova - Deputy Chief of the Department, Master’s degree in Health management, Doctor of the highest category;

Nazira Bekenova - Head of the clinical research sector in Department, PhD;

Balzhan Kassiyeva - Specialist in the clinical research sector of the Department, Master’s degree in Nursing;

Alisher Aitkaliev - specialist in the clinical research sector of the Department, Master’s degree in biotechnology.